What are the Differences between Serum and Plasma?

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Serum and plasma are types of blood specimens that are utilized in testing for the concentrations of substances in the blood. They are supernatant fluids obtained after centrifugation of clotted blood and noncoagulated blood, respectively.

Here are some differences between serum and plasma:

Category Serum Plasma
color light yellow lighter
transparency clearer than plasma less clear than serum
Serum protein present albumin, globulin albumin, globulin,  fibrinogen
anticoagulant absent present

Why is serum generally the most preferred blood specimen for clinical chemistry tests?

Serum is the preferred specimen because they have fewer proteins, which are considered as interfering substances for some tests.

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